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Raymond D Hickey Selected Research

Tyrosinemias (Tyrosinemia)

9/2020Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure.
4/2019Ex Vivo Hepatocyte Reprograming Promotes Homology-Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation.
1/2019Autologous Gene and Cell Therapy Provides Safe and Long-Term Curative Therapy in A Large Pig Model of Hereditary Tyrosinemia Type 1.
11/2018Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1.
1/2017Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1.
10/2016Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma.
1/2016Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1.
4/2015Noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene.
7/2014Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease.
10/2011Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer.

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Raymond D Hickey Research Topics

Disease

10Tyrosinemias (Tyrosinemia)
09/2020 - 10/2011
7Liver Diseases (Liver Disease)
09/2020 - 07/2014
4Acute Liver Failure (Fulminant Hepatic Failure)
09/2020 - 07/2014
4Liver Failure
09/2020 - 10/2011
3Hepatocellular Carcinoma (Hepatoma)
10/2016 - 10/2011
2Infections
11/2018 - 08/2015
2Fibrosis (Cirrhosis)
01/2017 - 10/2011
1Phenylketonurias (Phenylketonuria)
01/2021
1Metabolic Diseases (Metabolic Disease)
04/2019
1Inborn Errors Metabolism (Inborn Errors of Metabolism)
01/2019
1Thrombosis (Thrombus)
01/2018
1End Stage Liver Disease
01/2017
1Liver Cirrhosis (Hepatic Cirrhosis)
10/2016
1Coinfection
08/2015
1Drug Overdose
08/2015
1Brain Edema (Cerebral Edema)
08/2015
1Brain Diseases (Brain Disorder)
08/2015
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
07/2013

Drug/Important Bio-Agent (IBA)

11fumarylacetoacetase (fumarylacetoacetate hydrolase)IBA
09/2020 - 10/2011
4EnzymesIBA
09/2020 - 10/2011
3Tyrosine (L-Tyrosine)FDA Link
01/2017 - 07/2014
1Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA
01/2021
1Phenylalanine (L-Phenylalanine)FDA Link
01/2021
1Therapeutic UsesIBA
04/2019
1succinylacetoneIBA
10/2016
1Proteins (Proteins, Gene)FDA Link
08/2015
1AmmoniaIBA
08/2015
1RNA Splicing FactorsIBA
08/2015
1U2 Small Nuclear RibonucleoproteinIBA
08/2015
1Neuroprotective AgentsIBA
08/2015
1Small Interfering RNA (siRNA)IBA
08/2015
1Pharmaceutical PreparationsIBA
08/2015
1sodium-iodide symporter (sodium iodide symporter)IBA
04/2015
1Thyroxine-Binding GlobulinIBA
04/2015
1Polystyrenes (Polystyrene)IBA
09/2013
1N-(3,4,5-trichlorophenyl)succinimideIBA
09/2013
1SuspensionsIBA
09/2013

Therapy/Procedure

6Therapeutics
09/2020 - 07/2013
4Transplantation
09/2020 - 07/2014
3Liver Transplantation
01/2019 - 01/2017
2Cell- and Tissue-Based Therapy (Cell Therapy)
09/2020 - 01/2019
2Organ Transplantation
04/2019 - 01/2019
1Operative Surgical Procedures
11/2018
1Artificial Liver (Bioartificial Liver)
08/2015